The Five Mysteries Program was an audience participation radio series broadcast on the Mutual Broadcasting System from August 10, 1947 to March 27, 1950. In 1947-48 it aired on Sundays at 2pm.

Such mysteries were produced and syndicated (1945-48) to individual local radio stations as a "barter-trade" program to sell advertising to local merchants or trade the advertising announcements for goods, services or premiums, such as prizes awarded to listeners in radio station contests or promotions. To facilitate personalizing the shows to individual stations and insert the local ads, the producers put musical interludes in the shows with enough time for a local announcer to introduce the episode, present the advertiser's message and wrap things up with other local information.